yetO [2017-8-11 16:0:3]

cytochrome P450 (CYP102A2)/ NADPH-cytochrome P450 reductase

locus: BSU07250

pI: 5.73

mw: 119.26 kDa

protein length: 1061 aa

gene length: 3183 bp

function: fatty acid metabolism

product: NADPH-cytochrome P450 reductase

essential: no

ec: 1.6.2.4

synonyms: yfnJ

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.1|Electron transport and ATP synthesis] → [category|SW 2.1.3|Electron transport/ other]
• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.3|Lipid metabolism/ other]
• [category|SW 4|Lifestyles] → [category|SW 4.2|Sporulation] → [category|SW 4.2.1|Sporulation proteins] → [category|SW 4.2.1.5|Newly identified sporulation proteins (based on transcription profiling)]

Gene

Coordinates: 792,682 → 795,867

The protein

Catalyzed reaction/ biological activity

• oxidation of even- and odd-chain saturated and unsaturated fatty acids to the respective omega-3, omega-2 and omega-1 hydroxylated fatty acids [Pubmed|15375636]

Paralogous protein(s)

• [protein|4BA5214C441C6671CB7DAA3CACBCA5FC025BE0E6|YrhJ]

Structure

• [PDB|2X7Y] (from ''Bacillus megaterium''; 66% identity, 87% similarity) [Pubmed|25325618,22949185]

[SW|Localization]

• cytoplasm (according to Swiss-Prot)

Expression and Regulation

Operons

• genes: [gene|9AA8CAEB42B1ED4CC8D80D57B045A55307114D6A|yetO]
  description: [pubmed|22383849]

Biological materials

Mutant

• MGNA-C225 (yfnJ::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/2223 NBRP B. subtilis, Japan]

References

• 15122913,15375636,16716428,15857787,11734890,21048857,25325618,22949185